In 2010, she posed nude for the infamous Pirelli Calendar, which was photographed by Terry Richardson. Huntington-Whiteley hit the runway for designers Prada in Milan and Giles Deacon in Paris. For SS10 her advertising campaigns included Monsoon’s first underwear line, Thomas Wylde, Full Circle, and VS Online. In March, she collaborated with VOGUE.COM to share her outfit choices daily for the Today I’m Wearing feature. She appeared on the covers of the May 2010 issues of Harper’s Bazaar Russia and GQ UK. She was featured on the cover of LOVE Magazine’s September issue, styled as a pinup girl. For FW10 she modelled for Burberry as well as the company’s first Beauty line ad; her other advertising campaigns included Loewe, Thomas Wylde, and Leon Max. Fashion photographer Rankin devoted a book entirely to her titled, Ten Times Rosie. Rankin thinks Huntington-Whitely puts diversity back into fashion, “We’ve been looking at very, very skinny, almost masculine girls for a long time. Rosie really is the model of the moment. She’s the actress of the moment. She’s definitely going to become something much, much bigger.”

In March 2011, she landed her first solo British Vogue cover. In May, she was voted No. 1 in Maxim Magazine’s “Hot 100” list. She was also voted No.1 in FHM’s World’s Sexiest Woman 2011 poll. She appeared on the covers of the UK’s July issues of Elle and GQ.